Transplantation. Scope. (2019) 20:409. doi: 10.1186/s12882-019-1557-x, 23. The influence of continuous variables such as age on renal function was analyzed by Student's t-test, and categorical variables was analyzed by chi-square test. Cystatin C (CysC), also called cystatin 3, is a protein synthesized continuously by nucleated cells. Do Frontiers Journals have an Impact Factor? Background: Factors influencing the kidney function of patients after renal transplantation include both recipient-related factors and donor-related factors. firstname.lastname@example.org, For queries regarding Research Topics, Editorial Board applications, and journal development, please contact doi: 10.1111/j.1432-2277.2002.tb00205.x, 28. With our expedient, transparent and collaborative peer review, the Nephrology section of Frontiers in Medicine is an ideal outlet for disseminating rapid advances in renal research and for supporting innovations that can drive improve clinical outcomes and direct changes in future clinical practice. The type A blood group was the most frequent (33.5%). (2011) 365:318–26. Table 2. Risk factors for acute rejection after deceased donor kidney transplantation in China. Friday, April 26, 2019. It is possible that the largely Caucasian population in their research showed different general genetic influences and immunological mechanisms compared with our cohort population. Morath C, Zeier M, Döhler B, Opelz G, Süsal C. ABO-incompatible kidney transplantation. South America . doi: 10.1111/j.1600-6143.2012.04226.x, 36. Fax +41 (0)21 510 17 01, For technical issues, please visit our Frontiers Help Center, or contact our IT HelpDesk team at Impact Factor 3.9 | CiteScore 4.3More on impact ›. No statistical significance was found in the influence of preoperative hepatitis history, receiving secondary transplantation, dialysis type and time, blood type compatible/incompatible or relationship between donors and recipients on kidney function (P > 0.05). 2015(288)] before subjects participation in the study. (1999) 55:2011–20. Figure 1 displays the derivation of our research process including the inclusion and exclusion of subjects and the organization and analyses of data. Front. (2013) 45:129–33. In contrast, smaller recipients of larger donor kidneys have been linked to better long-term outcomes (10). All of these changes and new developments need to be properly and timely examined, summarized and presented to all stakeholders. Previously the “gold standard” diagnostic tool to assess graft failure was kidney biopsy. As for donor-related factors, the recipients receiving a kidney from a younger donor had significantly better impact on kidney function recovery as measured by CysC levels from 1 week to 3 years (P < 0.001) (Figure 4). Frontiers of Oral and Maxillofacial Medicine is published by AME Publishing Company. (2015) 68:57–69. It is useful to predict the postoperative renal function earlier according to corresponding factors, and improve the patient's quality of life. Variables which were statistically significant (P < 0.05) in the univariate analyses were entered into the multivariable logistic regression analyses hierarchically by discrete time points. Montgomery RA, Lonze BE, King KE, Kraus ES, Kucirka LM, Locke JE, et al. The goal of this study is to acquire information about inferior outcomes earlier to allow clinicians to make appropriate adjustments in therapy at specific time points, thereby enhancing the quality of life of patients. To gain a better understanding of the impact of donor- and recipient-related factors on kidney transplantation outcomes and to improve donor candidate evaluation and selection before surgery, we incorporated the effect of multiple factors on kidney function after renal transplantation in a larger population of southwestern Chinese people. The Official Publication of the Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine. The effect of donor-recipient gender mismatch on short- and long-term graft survival in kidney transplantation: a systematic review and meta-analysis. (2017) 17:250. doi: 10.1186/s12913-017-2190-7, 19. Consequently, it led to a higher proportion of O blood type among donors. Impact Factor 3.9 | CiteScore 4.3More on impact ›, All India Institute of Medical Sciences, India, Australian Red Cross Blood Service, Australia. N Engl J Med. College of Stomatology Shanghai Jiao Tong Univerity. (2018) 16:682–9. We aim at building a valuable resource for clinicians and researchers to exchange innovative ideas and practices and to access cutting-edge research on basic, clinical and translational nephrology. Clin Transplant. Non-Han patients have a faster CysC recovery than Han patients 3 months−2 years after surgery (P < 0.05). Impact Factor Calculations. Based on these results, it is possible to expand the living donor pool for patients which may reduce waiting time and minimize suffering before transplantation. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. FRONTIERS IN MEDICINE 2017. As an open access journal, Frontiers in Medicine is committed to empowering researchers and practitioners by providing an open and transparent resource to publish the latest breakthroughs in nephrology. As with many disciplines in medicine, nephrology has greatly benefited from recent scientific and technological advances, allowing nephrologists to improve diagnostics, therapy and treatment, ultimately leading to improved patient care. Oceania. Academic Accelerator; Fator de Impacto 2018-19; Frontiers in Medicine; Abreviatura (ISO4) Taxa de aceitação. The mean donor age was 46 years old and the age range was 1–68 years old. Heeger PS(1). Mills KT, Xu Y, Zhang W, Bundy JD, Chen CS, Kelly TN, et al. Prediction system for risk of allograft loss in patients receiving kidney transplants: international derivation and validation study. Additionally, the sample size of each research study has been limited, ranging from 300 to 600 participants (18, 20, 22). Kidney transplantation has revolutionized the treatment of CKD and is acknowledged as the most effective renal replacement therapy for people with ESRD by improving patient life expectancy and quality of life (3). In our study, kidneys were mainly from living donors which may be beneficial to better outcomes of recipients. Goldberg RJ, Smits G, Wiseman AC. ZX and LW searched the literature, performed the research, wrote, and revised the manuscript. doi: 10.7326/0003-4819-145-4-200608150-00004, 41. doi: 10.1111/ctr.12191, 6. J Natl Med Assoc. 3.900. Am J Transplant. (2011) 11:2132–43. While this method can precisely determine the condition of the graft and provide direct evidence for surgeons, it remains invasive and expensive, and is a complicated means to obtain samples. Continuous variables such as age were reported as the mean ± SD (standard deviation), and categorical variables were reported as frequencies (percentages). doi: 10.6002/ect.2018.0241, 17. This was linked to our kidney allocation principle. (2020) 26:22–34. Zhou JY, Cheng J, Huang HF, Shen Y, Jiang Y, Chen JH. Compatible ABO blood type was preferred, but when the matching was unsuccessful, the incompatible ABO kidney transplant was considered for reducing waiting time when kidney donors were extremely lacking. Younger donors had significantly better medium-and-long-term influence on kidney function. Transpl Int. The Journal Impact Quartile of Frontiers in Medicine is Q1. Risk factors for acute rejection in living-donor kidney transplant recipients in China: a subgroup analysis of a multi-center, registry study. First, analyzing factors univariately without combination may ignore the interaction and confounding impact on outcomes (11). Creatinine-based equations for estimation of GFR (eGFR) were established to overcome some of these inadequacies (40). Nunes-Dos-Santos DL, Gomes SV, Rodrigues VP, Pereira ALA. Periodontal status and clinical outcomes in kidney transplant recipients: a systematic review. Note that 2019 Journal Impact are reported in 2020; they cannot be calculated until all of the 2019 publications have been processed by the indexing agency. The Nephrology section of Frontiers in Medicine is open for submission of articles on symptoms, diagnosis, treatment, prognosis, follow up and improved or innovative treatments of kidney diseases and other renal disorders. Kidney transplantation from donors after cardiac death: an initial report of 71 cases from China. doi: 10.1111/j.1600-6143.2011.03640.x, 25. More evidence shows that testosterone and estrogens have contrasting effects on chronic allograft nephropathy. email@example.com. Transpl Int. Multivariate logistic regression analysis. BMJ. Each factor was statistically analyzed stratified by discrete time points after transplantation. This is understandable because BMI has a significant impact on gender-dependent responses to renal transplantation. 5.206. Transplantation. This may also explain why the recipient age is associated with short-term influence postoperatively in our study. Xue W, Tian P, Xiang H, Ding X, Pan X, Yan H, et al. (24), whose risk factors included female recipients. The outcome measurement for this study is the CysC value. More importantly, it had the advantages of better kidney quality, good HLA matching, short donor kidney ischemia time, and selective operation. Interestingly, a recent publication by Cohen et al. Transplantation. ZX, LW, and XL engaged in the acquisition of data (laboratory or clinical). Association of HLA mismatch with death with a functioning graft after kidney transplantation: a collaborative transplant study report. (2004) 78:635–40. While the recipient who received a kidney from an older donor was a risk factor for CysC recovery from 2 weeks to 2 years (P < 0.05, OR > 1), as well as the recipients with large BMI from 2 weeks to 1 month (P < 0.05, OR > 1). Univariate and multivariate logistic regression analyses were carried out on the study variables, and kidney function of postoperative patients was monitored using cystatin C (CysC) as the outcome indicator. This work was funded by grants from the National Natural Science Foundation of China (81472026 and 81870513), the Projects of the Health and family planning commission in Sichuan Province (18PJ101), and the Science and Technology Project of Chengdu (2017-CY02-00018-GX). Neri F, Furian L, Cavallin F, Ravaioli M, Silvestre C, Donato P, et al. From the multivariate logistic regression analysis, recipient gender, ethnicity, BMI, and donor age were independent factors affecting postoperative CysC recovery at discrete time points. Determination of CysC can diagnose early-stage renal dysfunction and monitor renal function over time (23). The Nephrology section provides a forum for innovative communication and cross-fertilization of rigorous basic, translational, and clinical research from physician/scientists/practitioners and trainees who aim to publish their strongest work in this section. Cohen JB, Owei L, Sawinski DL, Porrett PM. Kidney Int. 3.633. The results showed that the recipient gender, ethnicity, BMI, and donor age were independent factors affecting postoperative CysC recovery thus reflecting kidney function in renal transplant recipients (P < 0.05). doi: 10.1097/TP.0000000000002915, 7. Medicine Pharmacology (medical) Pharmacology, Toxicology and Pharmaceutics Pharmacology: Publisher: Frontiers Media S.A. Assessment of GFR also requires a 24 h urine collection which is not convenient and may be subject to additional preanalytical errors. Cystatin C: a step forward in assessing kidney function and cardiovascular risk. Frontiers journals lead in citations & rank in the top Impact Factor and CiteScore percentiles. CysC recovery rate was faster 2 weeks−1 month after surgery when the number of HLA A-B-DR-DQ loci mismatches was zero (P < 0.05), and compared with the 5–8 mismatch group, the rate of CysC recovery was statistically higher in the 0–4 mismatch group from 2 to 6 months after transplantation (P < 0.05), suggesting better recovery of kidney function when there are fewer mismatches (Figure 2). Risk factors for delayed graft function after renal transplantation and their significance for long-term clinical outcome. The type O blood group was the most frequent among the donors, accounting for 46.1%. Medicine Immunology and Allergy: Publisher: Frontiers Media S.A. J Am Coll Surg. Editors’ geographical locations. Note that 2019 Journal Impact are reported in 2020; they cannot be calculated until all of the 2019 publications have been processed by the indexing agency. (2017) 31:e13036. Received: 18 January 2020; Accepted: 19 October 2020; Published: 12 November 2020. The reference range of CysC is 0.51–1.09 mg/L, based on the biochemical laboratory test report of the Laboratory Medicine Department of West China Hospital. First, though the quantity of samples is large, this study is only a single-center retrospective analysis, certain restrictions not only in the region but also in the time period still exist. Pesquisa Popular. doi: 10.1097/01.tp.0000228233.09678.22, 9. Transplantation. The principle of kidney allocation was based on same blood type match priority as well as HLA matching criteria, which was synthetically considered. Nevertheless, one limitation of our study is that the various minorities were not studied separately to determine which minority may have the best graft condition because the sample size available for separate analysis of each national minority was small. In particular, in pathology, in the recent years we are witnessing great changes that involve not only the technical aspects, but also the aims and the mission of our discipline. In addition to the 2-year Journal Impact, the 3-year Journal Impact can provide further insights and factors into the impact of Frontiers in Neurology. Recipient and donor characteristics of the study population (n = 2,462). Lassus J, Harjola VP. As an open access journal, Infectious Diseases – Surveillance, Prevention and Treatment, Intensive Care Medicine and Anesthesiology. doi: 10.1093/ndt/gfu375, 37. Data extracted from the database for this analysis include: (1) Recipient-related factors: gender, age, BMI (calculated by height and weight), blood type, ethnicity, number of transplants, preoperative hepatitis history, type and duration of dialysis, and HLA A-B-DR-DQ loci mismatch; and (2) Donor-related factors: gender, age, blood type, and relationship to recipient. Meier-Kriesche HU, Arndorfer JA, Kaplan B. (C) Comparison of CysC normal percentage between groups of different ranges of recipients' BMI at different time points follow up after surgery. Med. There were 1,808 male recipients (73.4%). Journal Impact Prediction System displays the exact community-driven Metric without secret algorithms, hidden factors… for not knowing the ethnicity of donors. More than half of the recipients (51.9%) spent over 1 year on dialysis and the primary method of dialysis was hemodialysis (90.4%). Insights to the epidemiology, pathogenesis and immune processes underlying renal health challenges has led to the introduction of new therapies and treatments. (2013) 27:764–71. Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. The birth of a new medical journal is always exciting and at the same time a great challenge. Results: From the univariate analysis, several factors showed statistically significant short-term impact on kidney function based on CysC after kidney transplantation, including age, ethnicity, body mass index (BMI), and HLA A-B-DR-DQ loci mismatch. All of these changes and new developments need to be properly and timely examined, summarized and presented to all stakeholders. doi: 10.1016/j.transproceed.2018.03.063, 21. Med., 12 November 2020 Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. (2018) 18:1699–709. firstname.lastname@example.org Recently, optimizing long-term survival of transplant recipients has become a hot topic in the World Transplantation Congress (4). All authors contributed to the article and approved the submitted version. Long-term impact of donor-recipient size mismatching in deceased donor kidney transplantation and in expanded criteria donor recipients. Additionally, in HLA incompatible transplantation, pre-formed donor-specific HLA antibodies may have been present for many years before the transplant, and the level in the early post-transplant period may show large changes. In America, African Americans undergoing deceased donor renal transplantation have lower graft survival compared to Caucasian Americans (15). Baskin-Bey ES, Kremers W, Nyberg SL. Thirty-five recipients (1.4%) received secondary transplantation and 255 recipients (10.4%) had a history of hepatitis before operation. ABO incompatibility has long been regarded as a contraindication to kidney transplantation (12). Fu Q, Zhang H, Nie W, Deng R, Li J, Xiong Y, et al. A great number of first-in-man studies have been or are being performed in the field of ophthalmology. The outcomes have improved dramatically with the development of matching rules. It was established in 2007 as Frontiers of Medicine in China, obtaining its current name in 2011. Congratulations to our authors, reviewers and editors across all Frontiers journals – for pushing boundaries, accelerating new solutions, and helping all of us to live healthy lives on a healthy planet. Donor and recipient characteristics were enrolled and matched in the Transplant Center Database before transplantation. (B) Comparison of CysC normal percentage between Han and non-Han recipients at different time points follow up after surgery. Authors. To date, numerous studies have demonstrated that many donor- and recipient-related factors are associated with outcomes after kidney transplantation. doi: 10.1097/TP.0b013e31819f2024, 39. The datasets analyzed in this article are anonymous to protect patient privacy and are not publicly available. Recipient-related factors of both short-term and long-term impact on postoperative kidney function reflected by CysC value: (A) Comparison of CysC normal percentage between male and female recipients at different time points follow up after surgery. (2012) 17:251–61. (2018) 18:1914–23. However, these results were not totally consistent with Dunn et al. 1. Further, the CysC value reflects the estimated glomerular filtration rate (eGFR) and thus shows the kidney condition of postoperative patients.
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